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Monod-Wyman-Changeux model

Pronunciation: mon-o' wi'man shahn-zhew'

Definition: a model used to explain the allosteric form of cooperativity; in this model, an oligomeric protein can exist in two conformational states in the absence of the ligand; these states are in equilibrium, and the one that is predominant has a weaker affinity for the ligand (which binds to the protein in a rapid equilibrium fashion).

Synonym(s): concerted model

[Jacques L. Monod, Jeffries Wyman, Jean-Pierre Changeux]

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.