Pronunciation: mon-o' wi'man shahn-zhew'
Definition: a model used to explain the allosteric form of cooperativity; in this model, an oligomeric protein can exist in two conformational states in the absence of the ligand; these states are in equilibrium, and the one that is predominant has a weaker affinity for the ligand (which binds to the protein in a rapid equilibrium fashion).
Synonym(s): concerted model
[Jacques L. Monod, Jeffries Wyman, Jean-Pierre Changeux]
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Examples: glitazone, GI cocktail, etc.