minimal reacting dose
Definition: the minimal dose of a toxic substance causing a reaction, as manifested in the skin of a series of susceptible test animals; the assay is based on the development of a characteristic, minimal but definite, “standard,” focal inflammation (congestion and edema, induration, degenerative changes, and desquamation of epidermal cells).
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Examples: glitazone, GI cocktail, etc.
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