minimal lethal dose
- the minimal dose of a toxic substance or infectious agent that is lethal, as assayed in various experimental animals (the least amount of diphtheria toxin that, on an average, kills a 250-g guinea pig within 96 hours after subcutaneous inoculation); when followed by a subscript (generally “MLD50”), denotes the minimal dose that is lethal to a certain percentage (50%) of animals so assayed.
See: lethal dose
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Examples: glitazone, GI cocktail, etc.