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milbemycin

Pronunciation: mil-be-mi'sin

Definition: A macrocyclic lactone (macrolide) antiparasiticide used for prevention of heartworm caused by Dirofilaria immitis, treatment of Toxacara canis, Toxascaris leonina, Trichuris vulpis, and Ancylostoma caninum gastrointestinal (GI) parasites in heartworm-negative dogs; also has activity against ectoparasites such as Demodex sp.; in the avermectin family; derived from 5-didehydromilbemycin moiety from Streptomyces hygroscopicus aureolacrimosis; less toxic in Collies than ivermectin; given monthly orally. In cats, labeled for Dirofilaria immitis prevention, and treatment of GI parasites Toxocara cati and Ancylostoma tubaformae. Enhances gamma amino butyric acid release at the presynaptic membrane resulting in parasite paralysis and death. Not effective against flukes and tapeworms.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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