Pronunciation: mi-ka'lis men'ten
a hypothesis that a complex is formed between an enzyme and its substrate (also known as the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (also referred to as the Brown hypothesis), the latter step being the rate-determining step for the overall rate of substrate-product conversion.
[Leonor Michaelis, Maud L. Menten]
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Examples: glitazone, GI cocktail, etc.