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Medical Term:

Michaelis-Menten hypothesis

Pronunciation: mi-ka'lis men'ten

Definition: a hypothesis that a complex is formed between an enzyme and its substrate (also known as the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (also referred to as the Brown hypothesis), the latter step being the rate-determining step for the overall rate of substrate-product conversion.

[Leonor Michaelis, Maud L. Menten]

See Also: Michaelis-Menten constant, Michaelis-Menten equation

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