Pronunciation: mi-ka'lis men'ten
an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration; v = Vmax [S]/(Km + [S]), where v is the initial velocity of the reaction, Vmax is the maximum velocity, [S] is the initial substrate concentration, and Km is the Michaelis constant. Similar equations can be derived for conditions in which the product is present and for multisubstrate enzymes.
Synonym(s): Henri-Michaelis-Menten equation
[Leonor michaelis, Maud L. Menten]
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Examples: glitazone, GI cocktail, etc.