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membranoproliferative glomerulonephritis

 

Definition: chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix, and low serum levels of complement; occurs mainly in older children, with a variably slow progressive course, episodes of hematuria or edema, and hypertension. It is classified into three types: type 1, the most common, in which there are subendothelial electron-dense deposits; type 2, dense-deposit disease, in which the lamina densa is greatly thickened by extremely electron-dense material; type 3, in which there are both subendothelial and subepithelial deposits.

Synonym(s): hypocomplementemic glomerulonephritis, lobular glomerulonephritis, mesangiocapillary glomerulonephritis

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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