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mechanistic target of rapamycin


Definition: An intracellular serine/threonine protein kinase that plays a key role in various cellular functions (e.g., cell metabolism, growth, division, and survival). It is a member of the phosphatidylinositol-3-kinase-related kinase protein family. Inhibitors of this protein are used to prevent transplant rejection and as antineoplastic agents.

Synonym(s): mTOR, FK506 binding protein, FRAP1

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.