McCune-Albright syndrome

Pronunciation: mak-kyun' awl'brit

Definition: polyostotic fibrous dysplasia with irregular brown patches of cutaneous pigmentation and endocrine dysfunction, especially precocious puberty in girls. Infrequently, associated with primary hyperthyroidism gigantism or acromegaly, ACTH-independent Cushing syndrome, and chronic active (nonautoimmune or viral) hepatitis.

Synonym(s): Albright disease, Albright syndrome1

See Also: pseudohypoparathyroidism

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McCune-Albright syndrome

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