Pronunciation: mak-kyun' awl'brit
Definition: polyostotic fibrous dysplasia with irregular brown patches of cutaneous pigmentation and endocrine dysfunction, especially precocious puberty in girls. Infrequently, associated with primary hyperthyroidism gigantism or acromegaly, ACTH-independent Cushing syndrome, and chronic active (nonautoimmune or viral) hepatitis.
See Also: pseudohypoparathyroidism
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Examples: glitazone, GI cocktail, etc.