Definition: an index indicating the degree of maturation attained by the vaginal epithelium as adjudged by the cell types being exfoliated; serves as an objective means of evaluating hormonal secretion or response; represents the percentage of parabasal cells/intermediate cells/superficials, in that order; “shift to the left” indicates more immature cells on the surface (atrophy), while “shift to the right” indicates more mature epithelium.
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Examples: glitazone, GI cocktail, etc.
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