Definition: an experiment in which one looks fixedly with one eye (the other being closed), at a black dot on a card, on which is also marked a black cross; as the card is moved to or from the eye, at a certain distance the cross becomes invisible but appears again as the card is moved further; this proves the absence of photoreceptors where the optic nerve enters the eye.
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Examples: glitazone, GI cocktail, etc.