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Marchiafava-Bignami disease

Pronunciation: mahr-ke-a-fah'vah ben-yah'me

Definition: a disorder recognized primarily by its pathologic features, consisting of demyelination of the corpus callosum and cortical laminar necrosis involving the frontal and temporal lobes. Occurs predominantly in those with chronic alcoholism, particularly wine drinkers.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.