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malate dehydrogenase

 

Definition: an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.

Synonym(s): malic acid dehydrogenase, malic dehydrogenase, malic enzyme, pyruvic-malic carboxylase

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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