Definition: any anemia in which the average size of circulating erythrocytes is greater than normal, the mean corpuscular volume is 94 mcm3 or more (normal range, 82–92 mcm3), including such syndromes as pernicious anemia, sprue, celiac disease, macrocytic anemia of pregnancy, anemia of diphyllobothriasis..
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Examples: glitazone, GI cocktail, etc.
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