Definition: the classic English test of criminal responsibility (1843): “to establish a defense on the ground of insanity, it must be clearly proved that, at the time of committing the act, the party accused was laboring under such a defect of reasoning, from disease of the mind, as not to know the nature and quality of the act he was doing, or if he did know it, that he did not know he was doing what was wrong.”
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Examples: glitazone, GI cocktail, etc.