Definition: the change in site of production of the estrogen and progesterone essential for human pregnancy from the corpus luteum to the placenta; ovariectomy always terminates pregnancy in most mammals because their placentas never produce enough estrogen and progesterone, but, after the sixth week of pregnancy, a human placenta can produce enough of these hormones to prevent abortion despite ovariectomy.
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Examples: glitazone, GI cocktail, etc.