Definition: the limes reacting dose of diphtheria toxin, the smallest amount of toxin that, when mixed with one unit of antitoxin and injected intracutaneously in the shaved skin of a susceptible guinea pig, yields a minimal, positive reaction and inflammation localized to the region of the injection; the Lrd. closely approximates the Lod., as would be expected, inasmuch as a slight excess of unneutralized toxin results in a reaction.
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Examples: glitazone, GI cocktail, etc.
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