a modified version of natural human insulin, synthesized by a genetically programmed strain of nonpathogenic Escherichia coli, in which the amino acids lysine (Lys) and proline (Pro) near the end of the B chain are transposed. This chemical alteration yields an insulin with a much faster onset of action, which reaches its peak effect earlier than regular insulin.
[Lys + Pro]
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Examples: glitazone, GI cocktail, etc.