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lipoprotein-associated phospholipase 2


Definition: a protein associated with low-density lipoprotein (LDL) in human serum; expressed by macrophages and present in atherosclerotic lesions. Levels are elevated significantly in patients with coronary artery disease. Oxidized products of Lp-PLA2 are thought to be important factors in development of atherosclerosis because of their ability to attract macrophages and to lead to foam-cell formation.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.