Li-Fraumeni cancer syndrome
Pronunciation: le frah'men-e
Definition: familial breast cancer in young women, with soft-tissue sarcomas in children, brain tumors and other cancers in close relatives; autosomal dominant inheritance, caused by mutation in the P53 gene on chromosome 17p.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.