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Li-Fraumeni cancer syndrome

Pronunciation: le frah'men-e

Definition: familial breast cancer in young women, with soft-tissue sarcomas in children, brain tumors and other cancers in close relatives; autosomal dominant inheritance, caused by mutation in the P53 gene on chromosome 17p.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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