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leukotrienes

Pronunciation: lu'ko-tri'enz

Definition: Products of eicosanoid metabolism (usually, arachidonate) with several physiologic roles, such as mediation of inflammation and participation in allergic reactions; leukotrienes differ from the related prostaglandins and thromboxanes in that they do not have a central ring; so named because they were discovered in association with leukocytes and were initially determined to possess three conjugated double bonds; letters A–F identify the first six metabolites isolated, with subscript numbers to indicate the number of double bonds (leukotriene C4).

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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