Skip to Content
Medical Term:


Pronunciation: lu'ko-en-sef'a-lop'a-the

Definition: White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.

[leuko- + G. enkephalos, brain, + pathos, suffering]

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.