Definition: a delayed hypersensitivity reaction at the site of an intradermal injection of a lepromin, such as the Dharmendra antigen or Mitsuda antigen, in a lepromin test; the reactions, such as the Fernandez or Mitsuda reaction, are variable, occurring in 48 hours or 3–5 weeks, but are uniformly negative in lepromatous leprosy, borderline leprosy, and mid-borderline leprosy.
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Examples: glitazone, GI cocktail, etc.