Pronunciation: les'i-thin-ko-les'ter-ol as'il-trans'fer-as
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.
Synonym(s): lecithin acyltransferase
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Examples: glitazone, GI cocktail, etc.