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lecithin-cholesterol acyltransferase

Pronunciation: les'i-thin-ko-les'ter-ol as'il-trans'fer-as

Definition: An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.

Synonym(s): lecithin acyltransferase

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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