Definition: an obsolete, nonspecific test for altered proteins in spinal fluid. As originally used by Lange in 1912, the test was thought to be specific for neurosyphilis; however, this proved to be incorrect. Dilutions of spinal fluid are made in saline and to these a colloidal gold solution is added; if altered proteins are present, there is a color change or precipitate formed.
Synonym(s): gold sol test, Zsigmondy test
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