Definition: cirrhosis in which normal liver lobules are replaced by small regeneration nodules, sometimes containing fat, separated by a fairly regular framework of fine fibrous tissue strands (hob-nail liver); usually due to chronic alcoholism. Can cause severe impairment of liver function, portal hypertension with ascites and esophageal varices, and life-threatening complications.
Synonym(s): portal cirrhosis
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Examples: glitazone, GI cocktail, etc.