Definition: alternatives for L†, the limes tod dose of diphtheria toxin, the smallest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, results in death of the animal within 96 hours (based on the average in a series); on theoretic grounds, one might expect that the difference between the L+ and L0 doses would be identical to 1 MLD, but this is not so in actual practice; with various toxic filtrates, the difference may range from several to more than 100 MLDs, indicating that the toxin-antitoxin combination is not a firm chemical union that occurs in constant proportions.
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