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Medical Term:

Koshland-Némethy-Filmer model

Pronunciation: kosh'land nem'e-the fil'mer

Definition: an explanation of the allosteric form of cooperativity. In this model, in the absence of ligands, the oligomeric protein exists in only one conformation; on binding, the ligand induces a conformational change that may be transmitted to other subunits.

Synonym(s): Adair-Koshland-Némethy-Filmer model, induced fit model2

[Daniel E. Koshland, George Némethy, David L. Filmer]

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.