Pronunciation: kosh'land nem'e-the fil'mer
Definition: an explanation of the allosteric form of cooperativity. In this model, in the absence of ligands, the oligomeric protein exists in only one conformation; on binding, the ligand induces a conformational change that may be transmitted to other subunits.
[Daniel E. Koshland, George Némethy, David L. Filmer]
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Examples: glitazone, GI cocktail, etc.