Pronunciation: kosh'land nem'e-the fil'mer
Definition: an explanation of the allosteric form of cooperativity. In this model, in the absence of ligands, the oligomeric protein exists in only one conformation; on binding, the ligand induces a conformational change that may be transmitted to other subunits.
Synonym(s): Adair-Koshland-Némethy-Filmer model, induced fit model2
[Daniel E. Koshland, George Némethy, David L. Filmer]
Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.