Definition: a degenerative periodontal disease of adolescents in which the periodontal destruction is out of proportion to the local irritating factors present on the adjacent teeth; inflammatory changes become superimposed, and bone loss, migration, and extrusion are observed. Two forms are recognized: localized, in which the destruction is limited to the incisors and first molars; and generalized, involving all the teeth.
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Examples: glitazone, GI cocktail, etc.