Definition: one of the stigmata of infectious endocarditis: irregular, erythematous, flat, painless macules on the palms, soles, thenar and hypothenar eminences of the hands, tips of the fingers, and plantar surfaces of the toes; rarely a diffuse rash. In acute endocarditis the lesions may be hemorrhagic or purple.
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Examples: glitazone, GI cocktail, etc.