Pronunciation: i-sos'the-nyu're-a, i'so-sthe-
Definition: A state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity than that of protein-free plasma; specific gravity of the urine becomes fixed around 1.010, irrespective of the fluid intake.
[iso- + G. sthenos, strength, + ouron, urine]
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Examples: glitazone, GI cocktail, etc.