Definition: one of two enzymes that catalyze the conversion of threo-ds-isocitrate, the product of the action of both aconitase and isocitrate lyase, to a-ketoglutarate (2-oxoglutarate) and CO2; one of the isozymes uses NAD+ (participating in the tricarboxylic acid cycle), whereas the other uses NADP+.
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Examples: glitazone, GI cocktail, etc.