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ion channel disorders


Definition: a number of diseases, mostly inherited and episodic in nature, caused by dysfunction of the calcium, chloride, potassium, or sodium channels of nerve or muscle; the inherited myotonias and periodic paralyses are included in this category; there is usually dominant inheritance, with the primary defect due to mutations of gene encoding on locus 7q32, 17q, or 1q31-32.

Synonym(s): channelopathies

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.