- The first stage of tumor induction by a carcinogen; subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumor on subsequent exposure to a promoting agent (promotion).
- Starting point of replication or translation in macromolecule biosynthesis.
- Start of chemical or enzymatic reaction.
- The first step in a chain reaction.
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Examples: glitazone, GI cocktail, etc.