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Definition: If or IKf channels are responsible for spontaneous depolarization (“funny current” in the sinuatrial node and atrioventricular node (i.e., cardiac pacemaker cells). This funny current is caused by sodium-potassium flux and determines depolarization frequency and thus, heart rate.

Synonym(s): funny channels

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.