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idiopathic giant-cell


Definition: Severe and rapidly progressive immune-mediated inflammation of the cardiac muscle, which leads to heart failure, ventricular arrhythmias and often death. Although a T-cell-mediated process has been suggested as a cause, the pathomechanism and predisposing factors have not been well described. Case reports have suggested an association with other autoimmune disorders, such as regional enteritis.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.