Absent or reduced splenic function, usually due to surgical removal, congenital aplasia, tumor replacement, or splenic vascular accident. Red blood cell abnormalities, including the presence of inclusions, nucleated red blood cells, and target cells, are commonly present. Patients with hyposplenism are at increased risk of bacterial sepsis, especially due to infection by Pneumococcus.
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Examples: glitazone, GI cocktail, etc.