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hypokalemic periodic paralysis


Definition: a form of periodic paralysis in which the serum potassium level is low during attacks; onset usually occurs between the ages of 7–21 years; attacks may be precipitated by exposure to environmental cold, high carbohydrate meal, or alcohol, may last hours to days, and may cause respiratory paralysis; autosomal dominant caused by mutation in the muscle dihydropyridine (DHP)-sensitive calcium channel a-1-subunit (CACNL1A3) on chromosome 1q or X-linked inheritance.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.