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human epidermal growth factor receptor 1


Definition: A cell surface receptor tyrosine kinase acting as a ligand for epidermal growth factor or transforming growth factor ?. Overexpression or mutation of this receptor is seen in many tumor types, including lung cancer, head and neck cancer, colon cancer, anal cancer, and glioblastoma multiforme.

Synonym(s): EGFR1, HER1, ErbB-1

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.