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Howell-Jolly bodies

Pronunciation: how′ĕl zhō-lē′

Definition: spheric or ovoid eccentrically located granules, approximately 1 mcm in diameter, occasionally observed in the stroma of circulating erythrocytes, especially in stained preparations (as compared with wet unstained films); probably represent nuclear remnants, staining with dyes that are rather specific for chromatin; the significance of the bodies is not exactly known; they occur most frequently after splenectomy or in megaloblastic or severe hemolytic anemia.

Synonym(s): Jolly bodies

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.