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homogentisate 1,2-dioxygenase

Pronunciation: ho'mo-jen'tis-at di-oks'i-jen-as

Definition: An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria.

Synonym(s): homogentisic acid oxidase

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.