Pronunciation: ho'mo-jen'tis-at di-oks'i-jen-as
Definition: An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O2, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria.
Synonym(s): homogentisic acid oxidase
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Examples: glitazone, GI cocktail, etc.