Skip to Content


Pronunciation: hol'o-pros-en-sef'a-le

Definition: Impaired midline cleavage of the embryonic forebrain resulting in a wide spectrum of facial features from cyclopia with proboscis above the single eye at the most severe form to ocular hypertelorism and single central upper incisor at the mildest form. This spectrum of disorders is associated with chromosomal aberrations involving chromosomes 2, 3, 7, 13, 18 and 21.

[holo- + G. proso, forward, + enkephalos, brain]

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.