Pronunciation: hol'o sin'thas
Definition: An enzyme that catalyzes transfer of the 4'-phosphopantetheinyl residue from coenzyme A to a seryl residue of apo-ACP (acyl-carrier protein) to form holo-ACP, releasing adenosine 3',5'-bisphosphate; a required step if fatty acid biosynthesis is to function.
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Examples: glitazone, GI cocktail, etc.