Definition: an aggressive form of periodontal disease seen in patients infected with HIV. It has characteristics of HIV gingivitis combined with soft tissue ulceration, necrosis, and rapid destruction of the periodontium and bone. It resembles acute necrotizing ulcerative gingivitis (ANUG) but extends into the crestal bone, whereas ANUG is restricted to the soft tissue.
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Examples: glitazone, GI cocktail, etc.