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histoplasmosis

Pronunciation: his'to-plaz-mo'sis

Definition: A widely distributed infectious disease caused by Histoplasma capsulatum; occurs occasionally in outbreaks; usually acquired by inhalation of spores of the fungus in soil dust and manifested by a self-limited pneumonia. In patients with emphysema, infection may be chronic and cause pulmonary fibrocavitary disease resembling tuberculosis; in immunosuppressed patients, and rarely, in otherwise healthy persons, histoplasmosis may cause disseminated disease of the reticuloendothelial system, which is manifested by fever, emaciation, splenomegaly, and leukopenia.

Synonym(s): Darling disease

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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