high molecular weight kininogen
Definition: a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.
Synonym(s): Fitzgerald factor, Flaujeac factor, Williams factor
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