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high molecular weight kininogen


Definition: a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.

Synonym(s): Fitzgerald factor, Flaujeac factor, Williams factor

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.