Definition: Having different alleles at a given locus on the pair of chromosomes present in the diploid state; for example, having a normal beta globin gene (coding for normal hemoglobin, Hb A) at locus p15.5 on one chromosome 11 and an abnormal gene (coding for sickle-cell hemoglobin, Hb S) at the same locus on the other chromosome 11.
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Examples: glitazone, GI cocktail, etc.
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