Definition: human antibodies capable of binding to animal immunoglobulins and possibly of interfering with reaction of animal-derived antibodies and analyte, which comprise all immunoassays. The three groups of heterophile antibodies are polyspecific antibodies, antiimmunoglobulin antibodies, and high-specificity high-affinity antibodies against antigens from animal species. In clinical practice, the most important significance of heterophile antibodies is their use in diagnosing infectious mononucleosis.
Synonym(s): heterophil antibodies
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