Definition: an abnormal Hb with substitution of a valyl residue for a glutamyl residue at the sixth position of the β chain; the formula is α2Aβ2S, or, more specifically, α2Aβ26Glu→Val. Heterozygous state: sickle cell trait, no anemia, Hb S 20–45% of total, the rest Hb A. Homozygous state: sickle cell anemia, Hb S 75–100% of total, the rest Hb F or Hb A2.
Synonym(s): sickle cell hemoglobin
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.