Definition: a Hb of molecular formula ?2e2, found as a minor Hb in the early embryo; disappears by the third month of pregnancy in favor of hemoglobin Gower-2 and hemaglobin Portland and then by Hb F; the ? chain has 141 amino acid residues. Synthesis of the ? chain is deficient in cases of hydrops fetalis.
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Examples: glitazone, GI cocktail, etc.